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Bi-directional association between depression and HF: An electronic health records-based cohort study
William V Bobo1, Euijung Ryu2, Tanya M Petterson2
1Department of Psychiatry and Psychology, Mayo Clinic, Jacksonville, FL, USA.
Journal of Comorbidity
|January 25, 2021
Summary
This study found that depression increases the risk of heart failure (HF), and HF increases the risk of depression. These conditions have a two-way relationship, impacting patient health significantly.
Area of Science:
- Cardiology
- Psychiatry
- Health Informatics
Background:
- Depression and heart failure (HF) are significant public health concerns.
- The relationship between depression and HF is complex and may be bi-directional.
- Understanding this relationship is crucial for comprehensive patient care.
Purpose of the Study:
- To investigate the bi-directional relationship between depression and heart failure (HF).
- To determine if depression predicts incident HF and if HF predicts incident depression.
- To utilize longitudinal electronic health records (EHRs) for robust analysis.
Main Methods:
- Retrospective cohort study using EHR data from a large healthcare system.
- Identified cohorts of individuals with depression and HF, matched with unaffected referents.
- Followed cohorts to identify new diagnoses of the other condition, using Cox proportional hazard models adjusted for comorbidities.
Main Results:
- Individuals with depression had a significantly increased risk of developing new-onset HF (HR 2.08).
- Individuals with HF had a significantly increased risk of developing new-onset depression (HR 1.34).
- These associations remained significant after adjusting for 16 comorbid chronic conditions.
Conclusions:
- Evidence supports a bi-directional relationship between depression and HF.
- This relationship exists independently of age, sex, and multimorbidity.
- Findings highlight the importance of screening for both conditions in affected patients.
Keywords:
Depressionbi-directionalcardiovascular diseaseelectronic health recordsheart failuremajor depressive disorderrelationshipMore Related Videos
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