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Clearing Traffic Jams During Protein Translocation Across Membranes

Lihui Wang1, Yihong Ye1

  • 1Laboratory of Molecular Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, United States.

Frontiers in Cell and Developmental Biology
|January 25, 2021
PubMed
Summary

Cells possess quality control mechanisms to remove stuck proteins from translocation channels in the endoplasmic reticulum and mitochondria. These translocon-associated strategies ensure efficient protein biogenesis and cellular function.

Keywords:
UFM1endoplasmic reticulumprotein translocationribosome UFMylationribosome stallingribosome-associated quality controltranslocon cloggingtranslocon-associated quality control

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