Related Experiment Video
Updated: Nov 20, 2025

Ferric Chloride-induced Murine Thrombosis Models
Published on: September 5, 2016
Serpins in Hemostasis as Therapeutic Targets for Bleeding or Thrombotic Disorders
Elsa P Bianchini1, Claire Auditeau1, Mahita Razanakolona1
1HITh, UMR_S1176, Institut National de la Santé et de la Recherche Médicale, Université Paris-Saclay, Le Kremlin-Bicêtre, France.
Abstract:
Bleeding and thrombotic disorders result from imbalances in coagulation or fibrinolysis, respectively. Inhibitors from the serine protease inhibitor (serpin) family have a key role in regulating these physiological events, and thus stand out as potential therapeutic targets for modulating fibrin clot formation or dismantling. Here, we review the diversity of serpin-targeting strategies in the area of hemostasis, and detail the suggested use of modified serpins and serpin inhibitors (ranging from small-molecule drugs to antibodies) to treat or prevent bleeding or thrombosis.
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