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Related Experiment Videos

Chronic alcoholism and microbial keratitis.

L D Ormerod1, D S Gomez, D J Schanzlin

  • 1Department of Ophthalmology, University of Southern California, Los Angeles.

The British Journal of Ophthalmology
|February 1, 1988
PubMed
Summary

Chronic alcoholism is a significant risk factor for microbial keratitis, often unsuspected in patients. This condition alters microbial profiles and is linked to trauma and self-neglect.

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Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Addiction Medicine

Background:

  • Microbial keratitis is a serious eye infection.
  • Chronic alcoholism is a prevalent condition with systemic health implications.
  • The relationship between alcoholism and specific ocular infections requires further elucidation.

Purpose of the Study:

  • To investigate the prevalence and characteristics of microbial keratitis in patients with chronic alcoholism.
  • To identify predisposing factors and microbial pathogens associated with keratitis in this patient group.
  • To raise awareness among ophthalmologists regarding alcoholism as a potential risk factor.

Main Methods:

  • Retrospective analysis of hospital records for 227 patients with microbial keratitis.
  • Review of patient histories, clinical presentations, and microbiological data.
  • Assessment of predisposing factors, including trauma, ocular conditions, and self-neglect.

Main Results:

  • One-third of patients with microbial keratitis had associated chronic alcoholism, often undiagnosed on admission.
  • Distinct microbial profiles were observed, with coagulase-negative staphylococci, streptococci, moraxellae, and Gram-negative bacilli being prominent.
  • Pseudomonas aeruginosa was infrequently isolated.
  • Predisposing factors included trauma, exposure, bullous keratopathy, other ocular diseases, and self-neglect.

Conclusions:

  • Chronic alcoholism is an important, often overlooked, risk factor for microbial keratitis.
  • Alcoholism may contribute through nutritional, toxic, or immunological pathways.
  • Ophthalmologists should consider screening for chronic alcoholism in patients presenting with microbial keratitis.

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