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Related Concept Videos

Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

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Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
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Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

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Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
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Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

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The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
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Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

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Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
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Necrosis01:16

Necrosis

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Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
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Depolarizing Blockers: Pharmocokinetics01:19

Depolarizing Blockers: Pharmocokinetics

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Depolarizing blockers are administered through intravenous injection. Succinylcholine is the most common choice of depolarizing blockers in emergency clinical practices. Although they have a rapid onset, they readily diffuse away from the motor end plate into the extracellular fluid. They are metabolized by enzymes such as liver butyrylcholinesterase and plasma pseudocholinesterases. This produces a short duration of action, typically 5-10 minutes long, unlike nondepolarizing blockers, which...
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Updated: Nov 20, 2025

Preparing a Mice Model of Severe Acute Pancreatitis via a Combination of Caerulein and Lipopolysaccharide Intraperitoneal Injection
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Propofol-Induced Severe Necrotizing Pancreatitis.

Akarsh Parekh1,2, Howard Zhang3

  • 1Department of Medicine, Summa Health Systems, Barberton, OH.

ACG Case Reports Journal
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Propofol, a common sedative, can cause severe pancreatitis, a rare but life-threatening adverse event. This case highlights the importance of recognizing propofol-induced pancreatitis in patients undergoing endoscopic procedures.

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Establishment of a Mouse Severe Acute Pancreatitis Model using Retrograde Injection of Sodium Taurocholate into the Biliopancreatic Duct
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Area of Science:

  • Anesthesiology
  • Gastroenterology
  • Critical Care Medicine

Background:

  • Propofol is a widely utilized intravenous sedative-hypnotic agent for procedural sedation, particularly in gastrointestinal endoscopy.
  • Drug-induced pancreatitis is an uncommon clinical entity, often attributed to underdiagnosis.
  • Propofol-induced pancreatitis represents an exceedingly rare adverse event associated with this anesthetic.

Observation:

  • A 22-year-old healthy male developed acute upper gastrointestinal symptoms post-esophagogastroduodenoscopy under propofol sedation.
  • The patient was subsequently diagnosed with severe acute pancreatitis.
  • The clinical course was complicated by necrotizing pancreatitis, acute respiratory distress syndrome, and septic shock.

Findings:

  • This case illustrates an extremely rare instance of propofol-induced pancreatitis.
  • The patient experienced severe complications, including multi-organ dysfunction, underscoring the potential severity of this adverse reaction.
  • Early recognition and management are critical for improving outcomes.

Implications:

  • Increased clinical awareness of propofol-induced pancreatitis is crucial for timely diagnosis and intervention.
  • This case emphasizes the need to consider propofol as a potential etiology for pancreatitis in patients undergoing sedation.
  • Further research may be warranted to elucidate the mechanisms and risk factors for propofol-induced pancreatitis.