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Related Experiment Video

Updated: Nov 20, 2025

ADSC-sheet Transplantation to Prevent Stricture after Extended Esophageal Endoscopic Submucosal Dissection
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Esophageal regenerative therapy using cell sheet technology.

Takeshi Ohki1,2, Masakazu Yamamoto1

  • 1Department of Surgery, Institute of Gastroenterology, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo, 162-8666, Japan.

Regenerative Therapy
|January 25, 2021
PubMed
Summary
This summary is machine-generated.

Cell sheet technology shows promise for esophageal regenerative therapy. Clinical trials demonstrate its potential in preventing esophageal stricture after endoscopic submucosal dissection (ESD).

Keywords:
CMC, carboxymethyl celluloseCPC, cell-processing centerCell sheet technologyEBD, endoscopic balloon dilationECM, extracellular matrixEMR, endoscopic mucosal dissectionESD, endoscopic submucosal dissectionEndoscopic submucosal dissection (ESD)Endoscopic transplantationEsophageal strictureGMP, good manufacturing practiceOMECS, oral mucosal epithelial cell sheetPGA, polyglycolic acidPIPAAm, poly(N-isopropylacrylamide)PVDF, polyvinylidene difluorideRegenerative medicineSEMS, self-expandable metallic stentTAC, triamcinoloneTissue-engineered oral mucosal

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Area of Science:

  • Gastrointestinal Science
  • Regenerative Medicine
  • Tissue Engineering

Background:

  • Cell sheet technology is an emerging regenerative therapy.
  • Esophageal damage, particularly after endoscopic submucosal dissection (ESD), poses a significant clinical challenge, often leading to stricture.
  • Autologous oral mucosal epithelial cell sheets offer a potential solution for esophageal repair.

Purpose of the Study:

  • To review the pre-clinical and clinical research on esophageal regenerative therapy using cell sheet technology.
  • To evaluate the efficacy of cell sheet transplantation in preventing esophageal stricture post-ESD.
  • To discuss the theoretical aspects and future potential of cell sheet technology in gastrointestinal science.

Main Methods:

  • Research initiated with animal models in 2004.
  • Clinical trials conducted since 2012 in collaboration with Nagasaki University and Karolinska Institute.
  • Focus on endoscopic transplantation of cultured autologous oral mucosal epithelial cell sheets.

Main Results:

  • Successful suppression of esophageal stricture in cases following ESD.
  • No complications reported in clinical trials.
  • Demonstrated feasibility of endoscopic transplantation of cell sheets.

Conclusions:

  • Cell sheet technology, while nascent, holds significant potential for esophageal regenerative therapy.
  • Endoscopic transplantation of autologous oral mucosal epithelial cell sheets is a viable strategy for stricture prevention post-ESD.
  • Further research and development are warranted to fully realize the applications of cell sheet technology in gastrointestinal science.