Hypofibrinogenemia can be estimated by the predictive formula in aortic surgery

Area of Science:

• Cardiovascular Surgery
• Anesthesiology
• Hematology

Background:

• Aortic surgery frequently leads to significant bleeding.
• Hypofibrinogenemia is a common complication during aortic surgery.
• Effective hemostasis strategies are crucial for patient outcomes.

Purpose of the Study:

• To develop a predictive formula for serum fibrinogen level (SFL) at the termination of cardiopulmonary bypass (CPB).
• To validate the accuracy of the developed formula in a separate patient cohort.

Main Methods:

• Retrospective observational study of 267 patients (group A) undergoing aortic surgery.
• Multiple linear regression analysis used to create the predictive formula.
• Formula validated in a separate cohort of 60 patients (group B).

Main Results:

• A predictive formula for SFL at CPB termination was developed: SFL = 14.7 + (0.44 × preoperative SFL) - (0.14 × CPB time) + (0.64 × preoperative body weight) - (17.3 × lateral thoracotomy).
• The formula demonstrated statistical validity in group B (R² = 0.531, p < 0.001).

Conclusions:

• Serum fibrinogen levels after aortic surgery can be predicted using preoperative SFL, body weight, CPB duration, and surgical approach.
• The predictive formula is valuable for guiding hemostasis strategies and optimizing blood transfusion preparation.