Related Experiment Video

Updated: Nov 20, 2025

Collection of Alfalfa Root Exudates to Study the Impact of Di2-ethylhexyl Phthalate on Metabolite Production
06:46

Collection of Alfalfa Root Exudates to Study the Impact of Di2-ethylhexyl Phthalate on Metabolite Production

Published on: June 2, 2023

2.0K

Phthalate and Bisphenol Urinary Concentrations, Body Fat Measures, and Cardiovascular Risk Factors in Dutch

Carolina C V Silva1,2, Vincent W V Jaddoe1,2, Chalana M Sol1,2

  • 1The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.

Obesity (Silver Spring, Md.)
|January 25, 2021
PubMed

Insights

Urinary phthalates, like di-n-octyl phthalate (DNOP), are linked to childhood overweight and poor cardiovascular health. Bisphenols, including bisphenol A, may decrease body mass index (BMI) over time.

Area of Science:

  • Environmental health
  • Pediatric endocrinology
  • Cardiovascular epidemiology

Background:

  • Exposure to endocrine-disrupting chemicals (EDCs) like phthalates and bisphenols during childhood is a growing concern.
  • These chemicals are ubiquitous in consumer products and can interfere with normal growth and metabolic processes.
  • Understanding the long-term effects of EDC exposure on body composition and cardiovascular health is crucial for public health.

Purpose of the Study:

  • To examine the relationship between urinary phthalate and bisphenol concentrations at age 6 and body fat indicators.
  • To investigate associations with cardiovascular risk factors, including blood pressure and lipid profiles, at ages 6 and 10.
  • To assess the impact of these exposures on changes in body fat and cardiovascular risk from age 6 to 10 years.

Main Methods:

  • A cohort of 471 Dutch children had urinary phthalate and bisphenol levels measured at age 6.
  • Body mass index (BMI), fat mass index, android fat mass, blood pressure, glucose, insulin, and lipid concentrations were assessed at ages 6 and 10.
  • Statistical analyses were performed to determine associations between chemical exposures and health outcomes.

Main Results:

  • Increased di-n-octyl phthalate (DNOP) metabolite concentrations at age 6 were associated with a higher risk of overweight at both 6 and 10 years.
  • Higher DNOP levels correlated with increased fat mass index at age 6, elevated systolic blood pressure at age 10, decreased high-density lipoprotein cholesterol, and increased triglycerides from age 6 to 10.
  • Elevated total bisphenols and bisphenol A concentrations were linked to a decrease in BMI between ages 6 and 10.

Conclusions:

  • Urinary DNOP metabolites are associated with overweight and an adverse cardiovascular risk profile in children.
  • Exposure to total bisphenols and bisphenol A may be associated with a reduction in BMI during childhood.
  • These findings highlight the potential impact of common environmental chemicals on pediatric obesity and cardiovascular health.
Abstract

More Related Videos

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants07:08

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

6.3K
Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays08:28

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

6.3K

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Distribution01:17

Pharmacokinetics in Pediatric Patients: Drug Distribution

Drug distribution in the pediatric population exhibits unique challenges and considerations due to the physiological differences between children, particularly neonates and infants, and adults. A crucial aspect of pediatric pharmacology is understanding how these differences impact the pharmacokinetics of various drugs, necessitating age-specific dosing strategies to ensure efficacy and safety.Neonates and infants have a higher total body water content, ~75%–90% of their body weight,...
128
Cholesterol: Significance and Regulation01:29

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
1.0K