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Published on: December 19, 2020
Study on Laboratory Indicators Related to Lung Injury of Corona Virus Disease 2019
Insights
This study found that age and certain laboratory markers correlate with COVID-19 duration. Other markers indicate the severity of acute lung injury in coronavirus disease 2019 patients.
Area of Science:
- Infectious Diseases
- Pulmonology
- Clinical Medicine
Background:
- The COVID-19 pandemic, caused by a novel coronavirus, has led to a global health crisis with no specific treatments.
- Susceptibility is high due to a lack of pre-existing immunity.
- The rapid spread necessitates understanding disease progression and severity indicators.
Purpose of the Study:
- To investigate correlations between the time to negative RT-PCR results and laboratory indicators in COVID-19 patients.
- To compare laboratory findings and RT-PCR negativity duration between patients with different oxygenation index levels, indicating varying degrees of acute lung injury.
Main Methods:
- A retrospective study was conducted on 84 COVID-19 patients admitted between January 22 and February 25, 2020.
- Patients were categorized into two groups based on their oxygenation index (≤300 mmHg vs. >300 mmHg).
- Correlations between RT-PCR negative time, age, and various laboratory markers were analyzed.
Main Results:
- A positive correlation was observed between RT-PCR negative time and age, white blood cell (WBC) count, lactate dehydrogenase (LDH), and serum creatinine (SCr).
- Significant differences in fever duration, WBC count, lymphocyte count, C-reactive protein (CRP), liver enzymes (ALT, AST), albumin, LDH, SCr, D-dimer, and fibrinogen were found between the two oxygenation index groups.
- These findings suggest distinct laboratory profiles associated with disease duration and acute lung injury severity.
Conclusions:
- Age, WBC count, LDH, and SCr may influence the duration of COVID-19 viral shedding.
- Indicators such as fever, WBC count, lymphocyte count, CRP, liver enzymes, albumin, LDH, SCr, D-dimer, and fibrinogen are associated with the severity of acute lung injury in COVID-19 patients.
- These markers could aid in assessing prognosis and managing patients with coronavirus disease 2019.
Background:
Since December 2019, a series of pneumonia cases caused by COVID-19 emerged in Wuhan, Hubei Province, China. People are generally susceptible to COVID-19 because people lack immunity to this new virus. With the spread of this epidemic disease from Wuhan, a national outbreak soon appeared, and now many countries have this disease. Unfortunately, no effective drug for COVID-19 treatment has been found so far.
Methods:
We designed a retrospective study based on patients admitted to The Affiliated Infectious Hospital of Soochow University from January 22, 2020, to February 25, 2020, with diagnosed COVID-19. We analyzed correlations between RT-PCR negative time and laboratory indicators, then divided all cases into 2 groups according to oxygenation index, data of RT-PCR negative time and related laboratory indicators of the two groups were com-pared.
Results:
We collected 84 confirmed patients whose RT-PCR had turned negative, including 23 patients with the lowest oxygenation index ≤ 300 mmHg and 61 patients had > 300 mmHg. There was a positive correlation between the RT-PCR negative time and age, WBC count, LDH, SCr. There were statistically significant differences in fever numbers, WBC count, lymphocyte count, CRP, ALT, AST, albumin, LDH, SCr, D-dimer, and fibrinogen between the two groups based on the oxygenation index.
Conclusions:
Age, WBC count, LDH, and SCr may be related to the duration of COVID-19 disease. Fever, WBC count, lymphocyte count, CRP, ALT, AST, albumin, LDH, SCr, D-dimer, and fibrinogen are related to the severity of acute lung injury.
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