Metal-free syntheses of N-functionalized and NH-1,2,3-triazoles: an update on recent developments
1Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, 3001 Heverlee, Belgium. wim.dehaen@kuleuven.be.
Abstract:
An overview of the latest developments in the metal-free synthesis of non-benzo-fused N-functionalized and NH-1,2,3-triazoles is provided in this feature article. Synthetic studies that appeared from 2016 until August 2020 are organized according to a wide-ranging classification, comprising oxidative and eliminative azide-dipolarophile cycloadditions, diazo transfer reactions and N-tosylhydrazone-mediated syntheses. The newly developed methods constitute a significant contribution to the field of 1,2,3-triazole synthesis in terms of structural variation via either the exploration of novel reactions, or the exploitation of existing methodologies.
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