Related Experiment Video
Updated: Nov 20, 2025

Induction of Invasive Transitional Cell Bladder Carcinoma in Immune Intact Human MUC1 Transgenic Mice: A Model for Immunotherapy Development
Published on: October 30, 2013
[Corrigendum] Mutation of TGF‑β receptor II facilitates human bladder cancer progression through altered TGF‑β1
Jing Bian1, Bo Li2, Xiaoyong Zeng3
1Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China.
Abstract:
Subsequently to the publication of the above article, an interested reader drew to the authors' attention that, in Fig. 1B on p. 1552, the MCF‑7 and T24, and the A549 and ScaBER data panels, respectively, appeared to be strikingly similar. After having re‑examined the original data, the authors have realized that these pairings of data panels were indeed duplicates of each other. Essentially, errors were made in the labelling of the data panels pertaining to the separate experiments, and in the compilation of the published version of Fig. 1. The authors, however, were willing to repeat the affected experiments, and obtained results that were consistent with those of the experiments that had been originally performed. Consequently, the revised version of Fig. 1 is shown below, showing the new data for Fig. 1B. The results from the flow cytometric analysis demonstrated the abnormally high expression level of TGF‑β receptor II in T24 cells. The authors confirm that these data support the main conclusions presented in their paper, and are grateful to the Editor of International Journal of Oncology for allowing them this opportunity to publish a Corrigendum. They also apologise to the readership for any inconvenience caused. [the original article was published in International Journal of Oncology 43: 1549‑1559, 2013; DOI: 10.3892/ijo.2013.2065].
Related Concept Videos
TGF - β Signaling Pathway
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
mTOR Signaling and Cancer Progression
The mTOR pathway or the...
The Retinoblastoma Gene
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Cancer-Critical Genes II: Tumor Suppressor Genes
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Mitogens and the Cell Cycle

