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Updated: Nov 20, 2025

Elevated Plus Maze Test Combined with Video Tracking Software to Investigate the Anxiolytic Effect of Exogenous Ketogenic Supplements
Published on: January 7, 2019
[A review of the antidepressant properties of ketamine]
Charles Y Desfossés1, Pierre Blier2
1The Royal's Institute of Mental Health Research, 1145 Carling Avenue, Ottawa, ON, K1Z 7K4, Canada.
Abstract:
Major depression is a frequent and disabling disorder. Despite great developments in the field of psychopharmacology since the 1950's, delayed onset of action and treatment resistance to current pharmacological options, such as serotonin reuptake inhibitors, remain a therapeutic challenge. The recent discovery of the rapid antidepressant action of ketamine, an NMDA (N-methyl-D-aspartate) receptor antagonist, has brought a revolution to this field. This paper presents a comprehensive review of the clinical research on the antidepressant properties of ketamine as well as its presumed mechanisms of action.
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