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Published on: January 7, 2019
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An Analysis of Prolonged, Continuous Ketamine Infusions
Steven G Schauer1,2,3,4, Jason F Naylor5, William T Davis2,3,4
1Combat Mortality Prevention Division, US Army Institute of Surgical Research, JBSA Fort Sam Houston, San Antonio, TX, USA.
Military Medicine
|January 25, 2021
Summary
Low-dose ketamine infusions offer a stable alternative to opioids for prolonged analgesia and sedation in non-burn patients. This study highlights ketamine
Area of Science:
- Anesthesiology
- Pharmacology
- Critical Care Medicine
Background:
- Opioids pose significant risks of dependence and tolerance.
- Low-dose ketamine presents a hemodynamically stable analgesic alternative.
- Limited data exists on prolonged ketamine use in non-burn patients.
Purpose of the Study:
- To describe the effects and outcomes of continuous ketamine infusions exceeding 72 hours in non-burn patients.
- To evaluate ketamine as a potential alternative to opioid analgesia.
Main Methods:
- Retrospective analysis of electronic health records at Brooke Army Medical Center.
- Inclusion criteria: ketamine infusions >72 hours in non-burn patients.
- Data abstracted included demographics, vital signs, ketamine dosage/duration, and outcomes.
Main Results:
- 194 subjects met inclusion criteria; median age 39, 67% male.
- Mean ketamine infusion: 43.9 mg/h for 130.8 hours.
- 83.5% survived to discharge; stable vital signs observed during infusions.
Conclusions:
- Continuous ketamine infusions are a viable adjunct for analgesia and/or sedation.
- Ketamine may serve as an effective alternative to opioids in specific patient populations.
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