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Cyclophilin A: a key player for etiological agent infection
Yating Liao1, Dan Luo1, Kailan Peng1
1Institute of Pathogenic Biology, Hengyang Medical College, University of South China, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, No. 28, West Changsheng Road, Hengyang City, 421001, Hunan Province, People's Republic of China.
Applied Microbiology and Biotechnology
|January 25, 2021
Summary
Cyclophilin A (CypA) is crucial in viral, bacterial, and parasitic infections. CypA inhibitors show promise as host-targeting drugs against various infections and related diseases.
Area of Science:
- Immunology
- Virology
- Microbiology
- Pathology
Background:
- Cyclophilin A (CypA) is an abundant immunophilin involved in numerous cellular processes.
- CypA acts as an intracellular receptor for cyclosporine A and plays roles in various diseases.
- This review highlights CypA's multifaceted roles in infections caused by diverse etiological agents.
Purpose of the Study:
- To review the pivotal roles of Cyclophilin A (CypA) in infections.
- To explore CypA's interactions with viral, bacterial, and parasitic agents.
- To discuss the potential of CypA inhibitors as host-targeting therapeutic agents.
Main Methods:
- Literature review of studies on Cyclophilin A (CypA) and its involvement in infections.
- Analysis of CypA's interactions with viral proteins, bacterial toxins, and host cell structures.
- Summary of current research on CypA inhibitors as potential antiviral and anti-infective agents.
Main Results:
- CypA influences viral replication, often depending on host cell type and viral species.
- CypA is implicated in bacterial infections by regulating actin cytoskeleton, toxin translocation, and pathogen adhesion.
- CypA also impacts parasitic infections and host immune regulation.
Conclusions:
- CypA is a significant factor in the life cycle and pathogenesis of various infectious agents.
- CypA inhibitors demonstrate broad-spectrum antiviral activity and potential to overcome drug resistance.
- CypA inhibitors represent a promising host-targeting strategy for treating multiple infections and associated human diseases.
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