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Published on: October 10, 2020
Non-coding RNAs in cardiomyocyte proliferation and cardiac regeneration: Dissecting their therapeutic values
Xiaoxuan Dong1, Xiuyun Dong2, Feng Gao1
1Department of Cardiology, Provincial Key Lab of Cardiovascular Research, Second Affiliated Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, China.
Insights
Non-coding RNAs like microRNAs, long non-coding RNAs, and circular RNAs are key to repairing heart damage by stimulating cardiomyocyte proliferation. This review explores their mechanisms and therapeutic potential for cardiac regeneration.
Area of Science:
- Biomedical Science
- Molecular Biology
- Cardiology
Background:
- Cardiovascular diseases pose a significant global health burden.
- Heart injury from ischemia leads to disability and mortality.
- Endogenous cardiomyocyte proliferation is crucial for cardiac repair.
Purpose of the Study:
- To review the role of non-coding RNAs in cardiomyocyte proliferation and cardiac regeneration.
- To elucidate the mechanisms by which microRNAs, lncRNAs, and circRNAs regulate cardiac repair.
- To highlight the therapeutic potential of non-coding RNAs in treating heart damage.
Main Methods:
- Literature review of studies on non-coding RNAs and cardiac regeneration.
- Analysis of mechanisms regulating cardiomyocyte proliferation.
- Evaluation of therapeutic applications of non-coding RNAs.
Main Results:
- Non-coding RNAs, including miRNAs, lncRNAs, and circRNAs, are integral to cardiac proliferation and regeneration.
- These molecules modulate key pathways involved in repairing ischemic heart injury.
- Specific non-coding RNAs show promise as therapeutic agents for cardiac repair.
Conclusions:
- Non-coding RNAs represent a promising avenue for stimulating cardiomyocyte proliferation and cardiac regeneration.
- Targeting non-coding RNAs offers a potential strategy to combat cardiovascular diseases.
- Further research into non-coding RNA therapeutics could revolutionize cardiac repair strategies.
Abstract:
Cardiovascular diseases are associated with high incidence and mortality, contribute to disability and place a heavy economic burden on countries worldwide. Stimulating endogenous cardiomyocyte proliferation and regeneration has been considering as a key to repair the injured heart caused by ischaemia. Emerging evidence has proved that non-coding RNAs participate in cardiac proliferation and regeneration. In this review, we focus on the observation and mechanism that microRNAs (or miRNAs), long non-coding RNAs (or lncRNAs) and circular RNA (or circRNAs) regulate cardiomyocyte proliferation and regeneration to repair a damaged heart. Furthermore, we highlight the potential therapeutic role of some non-coding RNAs used in stimulating CMs proliferation. Finally, perspective on the development of non-coding RNAs therapy in cardiac regeneration is presented.
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