Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Anergy in jaundiced patients.

M Cainzos1, J Potel, J L Puente

  • 1Department of Surgery, Hospital General de Galicia, School of Medicine, University of Santiago de Compostela, Spain.

The British Journal of Surgery
|February 1, 1988
PubMed
Summary

Jaundice is linked to a weakened immune response, specifically delayed hypersensitivity. Patients with jaundice show significantly higher rates of anergy, increasing their risk of postoperative infections.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Bicarbonate enhances the in vitro antibiotic activity of kanamycin in Escherichia coli.

Letters in applied microbiology·2015
Same author

NOD2, CD14 and TLR4 mutations do not influence response to adalimumab in patients with Crohn's disease: a preliminary report.

Revista espanola de enfermedades digestivas·2010
Same author

Review of the guidelines for complicated skin and soft tissue infections and intra-abdominal infections--are they applicable today?

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2008
Same author

Heterogeneity in the activity of Mexican Helicobacter pylori strains in gastric epithelial cells and its association with diversity in the cagA gene.

Infection and immunity·2007
Same author

Association of NOD2/CARD15 mutations with previous surgical procedures in Crohn's disease.

Revista espanola de enfermedades digestivas·2005
Same author

Phenotypic characterization of ipaH+ Escherichia coli strains associated with yolk sac infection.

Avian diseases·2005

Area of Science:

  • Immunology
  • Gastroenterology
  • Clinical Medicine

Background:

  • Delayed hypersensitivity is a key immune function.
  • Jaundice, often caused by pancreatobiliary issues, may impact immune status.
  • Assessing immune function in jaundiced patients is crucial for understanding outcomes.

Purpose of the Study:

  • To investigate the delayed hypersensitivity response in patients with jaundice.
  • To compare immune function between jaundiced patients and healthy controls.
  • To explore the relationship between jaundice, anergy, and postoperative complications.

Main Methods:

  • A prospective study involving 119 subjects (60 jaundiced patients, 59 controls).
  • Utilized the Multitest technique to assess delayed hypersensitivity.
  • Classified subjects into immunocompetent, relatively anergic, and anergic groups.

Main Results:

  • Significantly lower immunocompetence (17% vs. 76%) and higher anergy (55% vs. 10%) in jaundiced patients compared to controls (P < 0.001).
  • No difference in anergy index between malignant and benign pancreatobiliary pathology.
  • Anergic and relatively anergic patients had a higher incidence of postoperative septic complications.

Conclusions:

  • Jaundice is associated with a significant impairment of delayed hypersensitivity (anergy).
  • Immune dysfunction in jaundiced patients correlates with increased risk of postoperative infections.
  • Delayed hypersensitivity testing can identify patients at higher risk for complications.

Related Experiment Videos