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Current knowledge of Krüppel-like factor 5 and vascular remodeling: providing insights for therapeutic strategies

Ziyan Xie1, Junye Chen2, Chenyu Wang1

  • 1Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100730, China.

Journal of Molecular Cell Biology
|January 25, 2021
PubMed

Insights

Krüppel-like factor 5 (KLF5) is crucial in vascular remodeling, a process underlying many diseases. Targeting KLF5 offers potential therapeutic strategies for cardiovascular disorders.

Area of Science:

  • Cardiovascular Biology
  • Molecular Medicine
  • Pathophysiology

Background:

  • Vascular remodeling is a key pathological process in various cardiovascular disorders.
  • Krüppel-like factor 5 (KLF5) has emerged as a significant regulator in cardiovascular diseases over the past two decades.

Purpose of the Study:

  • To review the functional and regulatory mechanisms of KLF5 in vascular remodeling.
  • To summarize the therapeutic potential of KLF5 in vascular disorders.

Main Methods:

  • Literature review of recent publications on KLF5.
  • Analysis of KLF5's role in biological processes relevant to vascular remodeling.
  • Examination of KLF5's downstream targets and signaling pathways.

Main Results:

  • KLF5 influences cell proliferation, phenotype switching, extracellular matrix deposition, inflammation, and angiogenesis.
  • KLF5 acts by modulating numerous downstream genes and signaling pathways involved in vascular remodeling.

Conclusions:

  • KLF5 plays an essential role in the development of vascular remodeling.
  • KLF5 represents a promising therapeutic target for vascular disorders.
Keywords:
Krüppel-like factor 5 (KLF5)angiogenesisdrug developmentinflammationmicroRNAvascular remodeling

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