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Lethal Alleles

Lethal Alleles

Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...

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Related Experiment Video

Updated: Nov 20, 2025

A Ferret Model of Inflammation-sensitized Late Preterm Hypoxic-ischemic Brain Injury

A Ferret Model of Inflammation-sensitized Late Preterm Hypoxic-ischemic Brain Injury

Published on: November 19, 2019

Taï Forest Virus Does Not Cause Lethal Disease in Ferrets.

Zachary Schiffman^1,2, Feihu Yan³, Shihua He²

¹Department of Medical Microbiology and Infectious Diseases, University of Manitoba, Winnipeg, MB R3E 0J9, Canada.

|January 26, 2021

Summary

Taï Forest virus (TAFV) does not cause lethal disease in ferrets, unlike other ebolaviruses. Ferrets inoculated intranasally showed mild symptoms but recovered, indicating TAFV is less pathogenic in this model.

Keywords:

Côte d’Ivoire ebolavirus TAFV Taï Forest virus animal model ebolavirus ferret filovirus pathogenesis viral hemorrhagic fever

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Area of Science:

Virology
Pathogenesis
Zoonotic Diseases

Background:

Filoviruses, including ebolaviruses, are zoonotic RNA viruses causing severe human disease.
Taï Forest virus (TAFV) is considered less pathogenic, with only one documented non-fatal human case.
Ferrets have emerged as a lethal model for several ebolaviruses.

Purpose of the Study:

To evaluate the suitability of the ferret model for studying Taï Forest virus (TAFV).
To understand the pathogenesis of TAFV in a mammalian model.

Main Methods:

Ferrets were inoculated with TAFV via intramuscular and intranasal routes.
Clinical signs, weight changes, viral RNA levels in blood and tissues, and humoral immune responses were monitored.

Main Results:

TAFV infection did not result in lethal disease in ferrets.
Intranasally inoculated ferrets showed transient mild-to-moderate weight loss but recovered.
Low viral RNA levels were detected in some animals, and all developed a GP-specific IgG response.

Conclusions:

The ferret is not a suitable model for lethal TAFV infection.
TAFV exhibits lower pathogenicity in ferrets compared to other ebolaviruses.
These findings contribute to understanding TAFV pathogenesis and host-virus interactions.