Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MiR-23c Regulates the Resistance to Gefitinib in EGFR Mutant Non-Small-Cell Lung Cancer Cells.

Cells·2026
Same author

Oligometastatic versus polymetastatic colon cancer: functional and genomic determinants of divergent metastatic trajectories.

Exploration of targeted anti-tumor therapy·2026
Same author

Imaging and AI in tertiary prevention of lung cancer: Narrative review and clinical perspectives.

Multidisciplinary respiratory medicine·2026
Same author

Emerging Strategies in the Diagnosis and Treatment of Pleural Mesothelioma: An Overview.

Thoracic cancer·2026
Same author

Cabozantinib and temozolomide in patients with advanced progressive neuroendocrine tumors: a phase 2 study.

Nature communications·2026
Same author

Mining cancer genomes for copy number alterations identifies glycosylation enzymes as oncogenic drivers.

Proceedings of the National Academy of Sciences of the United States of America·2026

Related Experiment Video

Updated: Nov 20, 2025

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

10.7K

Surgery in Small-Cell Lung Cancer.

Nicola Martucci1, Alessandro Morabito2, Antonello La Rocca1

  • 1Thoracic Surgery, Istituto Nazionale Tumori, "Fondazione G. Pascale"-IRCCS, 80131 Naples, Italy.

Cancers
|January 26, 2021
PubMed
Summary

Surgery offers improved survival for select early-stage small-cell lung cancer (SCLC) patients. Multimodal treatment including surgery, chemotherapy, and radiotherapy is recommended by international guidelines for resectable stage I SCLC.

Keywords:
chemotherapylobectomymultimodal treatmentpneumonectomyradiotherapysmall-cell lung cancer

More Related Videos

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction
08:26

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction

Published on: March 24, 2023

957
Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors
05:16

Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors

Published on: February 19, 2022

6.3K

Related Experiment Videos

Last Updated: Nov 20, 2025

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
04:04

Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

Published on: February 12, 2017

10.7K
Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction
08:26

Clinical Application of Single-Surgeon, Three-Port, Laparoscopic Resection for Colorectal Cancer with Natural Orifice Specimen Extraction

Published on: March 24, 2023

957
Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors
05:16

Laparoscopy-endoscopy Cooperative Surgery for the Treatment of Gastric Gastrointestinal Stromal Tumors

Published on: February 19, 2022

6.3K

Area of Science:

  • Oncology
  • Thoracic Surgery

Background:

  • Small-cell lung cancer (SCLC) is highly aggressive with early metastasis.
  • Early-stage SCLC (T1,2 N0M0) has a better prognosis, with up to 50% 5-year survival.
  • Historically, surgery for early SCLC was discouraged due to negative early trial results.

Purpose of the Study:

  • To evaluate the role of surgery in early-stage SCLC management.
  • To review evidence supporting a multimodal approach including surgery for resectable SCLC.
  • To align with current international guidelines for SCLC treatment.

Main Methods:

  • Review of historical randomized phase III trials.
  • Analysis of subsequent prospective and retrospective studies.
  • Examination of large, population-based studies over the last 40 years.
  • Assessment of international guideline recommendations.

Main Results:

  • Early studies showed negative surgical outcomes.
  • Subsequent studies demonstrate feasibility and benefit of multimodal therapy including surgery.
  • 5-year survival rates of 36-63% reported for completely resected stage I SCLC.
  • Lobectomy with mediastinal lymphadenectomy is the standard surgical approach for selected patients.

Conclusions:

  • Surgery, as part of a multimodal treatment, improves outcomes for selected early-stage SCLC patients.
  • International guidelines recommend surgical resection for adequate-staged, resectable stage I SCLC.
  • Multidisciplinary evaluation is crucial for determining surgical candidacy in SCLC.