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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
602
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

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Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

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The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport01:23

Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport

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Drugs need to permeate cell membranes to reach their target sites after administration. Orally administered drugs must transcend intestinal epithelial membrane barriers to infiltrate the systemic circulation. Drugs with a molecular weight of less than 500 Daltons diffuse through gaps between neighboring cells, called paracellular pathways.
However, most drugs use the transcellular route, traversing directly through the cell membranes via two mechanisms: passive and active transport. Passive...
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Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

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The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
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Manufacture and Drug Delivery Applications of Silk Nanoparticles
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Concepts on Smart Nano-Based Drug Delivery System.

Shweta Rai1, Neeraj Singh1, Sankha Bhattacharya1

  • 1ISF College of Pharmacy, GT Road (NH-95), Ghal Kalan, Moga, Punjab 142001, India.

Recent Patents on Nanotechnology
|January 26, 2021
PubMed
Summary

This review explores smart nanocarriers for targeted drug delivery, highlighting their stability, efficacy, and diverse biomedical applications. Nanoparticles offer advanced solutions for treating diseases and developing innovative medical devices.

Keywords:
Liposomesdendrimersmesoporous silica nanoparticlespolymeric nanoparticlessolid lipid nanoparticles

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Area of Science:

  • Nanomedicine and nanoscale science applications in healthcare.
  • Focus on advanced drug delivery systems and biomedical technologies.

Background:

  • Nanomedicine leverages nanoscale science for targeted drug delivery using nanocarriers.
  • Nanocarriers offer enhanced stability, specificity, and efficacy for both hydrophobic and hydrophilic drugs.

Purpose of the Study:

  • To review various smart nano-based drug delivery systems.
  • To discuss the endocytic pathways involved in nanoparticle uptake.

Main Methods:

  • Review of existing literature on nanocarriers and their applications.
  • Analysis of different types of nanocarriers, including liposomes, nanoparticles, and nanotubes.

Main Results:

  • Identified numerous nanocarriers (liposomes, solid-lipid nanoparticles, dendrimers, etc.) as effective drug delivery systems.
  • Highlighted the versatility of nanoparticulate systems in forming various dosages and routes of administration.
  • Emphasized their broad applications beyond drug delivery, including sensors and optical devices.

Conclusions:

  • Smart nanocarriers represent a significant advancement in drug delivery and nanomedicine.
  • These systems offer promising therapeutic potential and diverse biomedical applications.
  • Understanding nanoparticle uptake pathways is crucial for optimizing nanomedicine efficacy.