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Updated: Nov 20, 2025

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
Published on: June 2, 2015
Performance of age-adjusted D-dimer values for predicting DVT before the knee and hip arthroplasty
Jian Xiang Wu1,2, Jiang Hui Qing2, Yao Yao2
1Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, School of Nanjing Medical University, 321 Zhongshan Road, Nanjing, 210008, Jiangsu, P.R. China.
Purpose:
To compare the specificity and sensitivity of preoperative D-dimer and age-adjusted D-dimer value for predicting the incidence of the DVT preoperatively in total joint arthroplasty (TJA) patients.
Methods:
We enrolled 406 patients finally above 50 years old. Everyone had done ultrasonography bedside, and D-dimer concentrations were collected before surgery. The D-dimer and age-adjusted D-dimer cut-off was calculated by multiple logistic regression and receiver operating curve (ROC) analyses.
Results:
A total of 39 patients had found asymptomatic deep vein thrombosis (DVT) by ultrasonography. The age (odds ratio [OR] 1.067; p = 0.003) and D-dimer (OR 1.331; p = 0.025) were related to the existence of DVT. For conventional D-dimer and age-adjusted D-dimer value, the area under the curves (AUCs) were 0.685 (0.499-0.696) and 0.795 (0.611-0.881), respectively.
Conclusion:
Compared to traditional D-dimer, age-adjusted D-dimer showed better performance in screening DVT, which was useful clinically.
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