Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Overview of DNA Repair02:25

Overview of DNA Repair

32.8K
In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...
32.8K
Overview of DNA Repair02:25

Overview of DNA Repair

8.8K
8.8K
Nucleotide Excision Repair01:38

Nucleotide Excision Repair

4.4K
DNA Distortion and Damage
Cells are regularly exposed to mutagens—factors in the environment that can damage DNA and generate mutations. UV radiation is one of the most common mutagens and is estimated to introduce a significant number of changes in DNA. These include bends or kinks in the structure, which can block DNA replication or transcription. If these errors are not fixed, the damage can cause mutations, which in turn can result in cancer or disease depending on which sequences are...
4.4K
Nucleotide Excision Repair01:08

Nucleotide Excision Repair

39.8K
Overview
39.8K
DNA Damage can Stall the Cell Cycle02:37

DNA Damage can Stall the Cell Cycle

9.7K
In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
9.7K
DNA Damage Can Stall the Cell Cycle02:37

DNA Damage Can Stall the Cell Cycle

2.9K
2.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular pathways driving clarithromycin benefit in community-acquired pneumonia: analysis of the ACCESS randomised trial.

EBioMedicine·2026
Same author

Molecular evolution of animal aging.

The EMBO journal·2026
Same author

DNA damage in macrophages drives immune autoreactivity via nuclear antigen presentation.

Nature aging·2026
Same author

Spotlight on innovation: key insights from the extracellular vesicle cluster meeting at the European Innovation Council.

Cytotherapy·2025
Same author

Author Correction: ERCC1-XPF cooperates with CTCF and cohesin to facilitate the developmental silencing of imprinted genes.

Nature cell biology·2025
Same author

From Genome to Geroscience: How DNA Damage Shapes Systemic Decline.

BioEssays : news and reviews in molecular, cellular and developmental biology·2025
Same journal

Introducing lesion-level metrics for melanocytic neoplasm clustering: Practical tools with potential applications in clinical practice.

The Journal of investigative dermatology·2026
Same journal

Reducing plastic waste in skin-model research: Sustainable packaging as a practical first step.

The Journal of investigative dermatology·2026
Same journal

Modern serum proteomics in precision medicine: Toward disease stratification and predictive, proactive treatment strategies.

The Journal of investigative dermatology·2026
Same journal

An Integrated Skin Cell Atlas Decodes the Pilosebaceous Unit.

The Journal of investigative dermatology·2026
Same journal

Residual CSB activity explains mild UV-sensitive syndrome phenotype caused by CSB mutations.

The Journal of investigative dermatology·2026
Same journal

Charting a new melanoma risk factor: Satellite Naevus Prevalence in High-Risk and Population-Based Cohorts.

The Journal of investigative dermatology·2026
See all related articles

Related Experiment Video

Updated: Nov 20, 2025

Author Spotlight: Combining Proximity Ligand Assay with Gamma-H2AX Staining to Characterize Protein Interactions in DNA Damage Response
09:39

Author Spotlight: Combining Proximity Ligand Assay with Gamma-H2AX Staining to Characterize Protein Interactions in DNA Damage Response

Published on: August 2, 2024

734

DNA Damage and the Aging Epigenome.

Athanasios Siametis1, George Niotis1, George A Garinis1

  • 1Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology, Heraklion, Greece; Department of Biology, University of Crete, Heraklion, Greece.

The Journal of Investigative Dermatology
|January 26, 2021
PubMed
Summary
This summary is machine-generated.

Genome instability and DNA damage accelerate aging by causing epigenetic alterations. This review explores how persistent DNA damage impacts the epigenome, affecting cell function and age-related diseases.

More Related Videos

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
12:15

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter

Published on: May 29, 2019

9.0K
Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
10:59

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

3.9K

Related Experiment Videos

Last Updated: Nov 20, 2025

Author Spotlight: Combining Proximity Ligand Assay with Gamma-H2AX Staining to Characterize Protein Interactions in DNA Damage Response
09:39

Author Spotlight: Combining Proximity Ligand Assay with Gamma-H2AX Staining to Characterize Protein Interactions in DNA Damage Response

Published on: August 2, 2024

734
Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter
12:15

Quantification of three DNA Lesions by Mass Spectrometry and Assessment of Their Levels in Tissues of Mice Exposed to Ambient Fine Particulate Matter

Published on: May 29, 2019

9.0K
Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage
10:59

Visualizing and Quantifying Endonuclease-Based Site-Specific DNA Damage

Published on: August 21, 2021

3.9K

Area of Science:

  • Genetics and Epigenetics
  • Aging Research
  • Molecular Biology

Background:

  • Genome instability and aging are closely linked in mammals.
  • DNA damage was traditionally linked to aging via transcription/replication issues, leading to malfunction and cancer.
  • Emerging evidence implicates DNA lesions in widespread epigenetic alterations that disrupt cellular homeostasis with age.

Purpose of the Study:

  • To review the functional connections between persistent DNA damage and the epigenome.
  • To discuss the role of these interactions in aging and age-related diseases.

Main Methods:

  • Literature review of recent scientific evidence.
  • Synthesis of findings on DNA damage, epigenetics, and aging.

Main Results:

  • Persistent DNA damage induces significant epigenetic changes.
  • These epigenetic alterations contribute to cellular dysfunction and aging.
  • The interplay between DNA damage and epigenetics is crucial in age-related pathologies.

Conclusions:

  • DNA damage is a key driver of aging through epigenetic modifications.
  • Understanding these links is vital for addressing age-related diseases.
  • Further research into DNA damage-epigenome interactions is warranted.