Indexing Cerebrovascular Health Using Transcranial Doppler Ultrasound

Transcranial Doppler (TCD) blood flow velocity has been extensively used in biomedical research as it provides a cost-effective and relatively simple approach to assess changes in cerebral blood flow dynamics and track cerebrovascular health status. In this article we introduce a new TCD-based timing index, TI_TCD, as an indicator of vascular stiffening and vascular health. We investigate the correlations of the new index and the existing indices, namely the pulsatility index and the augmentation index, with age, cardiorespiratory fitness (CRF) and magnetic resonance imaging (MRI) blood flow pulsatility index (PI_MRI). Notably, the new index showed stronger correlations with CRF (r = -0.79) and PI_MRI (r = 0.53) compared with the augmentation index (r = -0.65 with CRF and no significant correlation with PI_MRI) and the pulsatility index (no significant correlations with CRF or PI_MRI), and a similar correlation with age as the augmentation index. The clearer relationship of the proposed timing index with vascular aging factors underlines its utility as an early indicator of vascular stiffening.