Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

8.7K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.7K
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

9.8K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Rat somatic genome editing enables ER+ breast cancer modeling.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Cigarette smoke induces FASN-dependent fatty acid metabolic rewiring to drive bladder cancer progression.

Cancer letters·2026
Same author

Development of a multiplex assay for early detection of pancreatic cancer in high-risk groups.

BMC cancer·2026
Same author

Global impact of germline structural variation on the cancer proteome.

Nature communications·2026
Same author

EMT-induced stem cell and mesenchymal programs can be decoupled via cell division and ESRP1-dependent mechanisms.

iScience·2026
Same author

Osimertinib activates a TGF-β2-dependent secretory program that drives lung adenocarcinoma progression.

The Journal of clinical investigation·2025

Related Experiment Video

Updated: Nov 20, 2025

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.1K

Portals for Exploring Noncoding Variants in Pediatric Cancer.

Chad J Creighton1

  • 1Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA; Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA; Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.

Trends in Genetics : TIG
|January 26, 2021
PubMed
Summary

Zhou et al. introduce GenomePaint, a web portal for exploring cancer genomic alterations. This tool visualizes multiple omics data types across thousands of pediatric tumors, aiding cancer research.

More Related Videos

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
14:06

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER

Published on: June 23, 2012

15.5K
Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
09:33

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

1.4K

Related Experiment Videos

Last Updated: Nov 20, 2025

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information
09:37

Navigating MARRVEL, a Web-Based Tool that Integrates Human Genomics and Model Organism Genetics Information

Published on: August 15, 2019

10.1K
Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER
14:06

Detection of Rare Genomic Variants from Pooled Sequencing Using SPLINTER

Published on: June 23, 2012

15.5K
Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens
09:33

Author Spotlight: Finding New Therapeutic Targets for Malignant Peripheral Nerve Sheath Tumor Through Genome-Scale shRNA Screens

Published on: August 25, 2023

1.4K

Area of Science:

  • Genomics
  • Cancer Research
  • Bioinformatics

Background:

  • Understanding noncoding somatic alterations is crucial for cancer research.
  • Integrating diverse omics data provides a comprehensive view of cancer genomes.
  • Existing tools may lack dynamic visualization or comprehensive data integration.

Purpose of the Study:

  • To present GenomePaint, a dynamic web-based portal.
  • To facilitate the exploration of noncoding somatic alterations in cancer by genomic location.
  • To enable integrated visualization of multiple omics data platforms.

Main Methods:

  • Development of a dynamic web-based data portal named GenomePaint.
  • Integration of data from whole-genome, whole-exome, transcriptome, and epigenome sequencing.
  • Inclusion of data from over 3800 pediatric tumors.
  • Implementation of user data upload functionality.

Main Results:

  • GenomePaint allows simultaneous visualization of multiple omics data types.
  • The portal provides a platform for exploring cancer alterations by genomic location.
  • It incorporates a substantial dataset of pediatric tumor omics data.
  • Users can upload and analyze their own datasets.

Conclusions:

  • GenomePaint offers a valuable resource for cancer genomics research.
  • Integrated visualization of multi-omics data enhances the understanding of noncoding alterations.
  • The portal supports collaborative research and data sharing in oncology.