Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interferon-β Deficiency Selectively Modulates Chronic Microglial Pathways after Traumatic Brain Injury.

Journal of neurotrauma·2026
Same author

Adipose tissue-brain crosstalk in comorbid obesity and traumatic brain injury: Insights into mechanisms.

Neural regeneration research·2025
Same author

Unraveling the complexity of microglial responses in traumatic brain and spinal cord injury.

Handbook of clinical neurology·2025
Same author

Impact of obese body mass index on inflammasome blood biomarkers and neurocognitive performance following traumatic brain injury with Glasgow coma scale 13 to 15.

Journal of the neurological sciences·2024
Same author

Molecular Pathway Changes Associated with Different Post-Conditioning Exercise Interventions After Experimental TBI.

Journal of neurotrauma·2024
Same author

Applying Dynamical Systems Theory to Improve Personalized Medicine Following Mild Traumatic Brain Injury.

Neurotrauma reports·2024

Related Experiment Video

Updated: Nov 20, 2025

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.4K

Bidirectional Brain-Systemic Interactions and Outcomes After TBI.

Alan I Faden1, James P Barrett1, Bogdan A Stoica1

  • 1Department of Anesthesiology and Shock, Trauma and Anesthesiology Research (STAR) Center, University of Maryland School of Medicine, Baltimore, MD, USA.

Trends in Neurosciences
|January 26, 2021
PubMed
Summary
This summary is machine-generated.

Traumatic brain injury (TBI) impacts organs beyond the brain, affecting recovery and long-term neurological health. This review explores the bidirectional communication between the brain and body after TBI.

Keywords:
bidirectionalmicroglianeuroinflammationsystemictraumatic brain injury

More Related Videos

Controlled Cortical Impact Model for Traumatic Brain Injury
05:30

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

29.2K
Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

15.6K

Related Experiment Videos

Last Updated: Nov 20, 2025

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury
07:21

Systems Analysis of the Neuroinflammatory and Hemodynamic Response to Traumatic Brain Injury

Published on: May 27, 2022

3.4K
Controlled Cortical Impact Model for Traumatic Brain Injury
05:30

Controlled Cortical Impact Model for Traumatic Brain Injury

Published on: August 5, 2014

29.2K
Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury
10:59

Investigations on Alterations of Hippocampal Circuit Function Following Mild Traumatic Brain Injury

Published on: November 19, 2012

15.6K

Area of Science:

  • Neuroscience
  • Systemic Physiology
  • Traumatology

Background:

  • Traumatic brain injury (TBI) is a major cause of death and disability.
  • TBI is linked to chronic neurodegeneration and long-term neurological decline.
  • Emerging evidence indicates TBI affects multiple systemic organs.

Purpose of the Study:

  • To review the bidirectional interactions between the brain and systemic organs post-TBI.
  • To critically assess the mechanisms underlying these interactions.
  • To highlight the impact of systemic changes on neurological outcomes.

Main Methods:

  • Literature review of preclinical and clinical studies.
  • Analysis of evidence on organ system dysfunction following TBI.
  • Examination of proposed molecular and physiological mechanisms.

Main Results:

  • TBI significantly impacts pulmonary, gastrointestinal, cardiovascular, renal, and immune systems.
  • Systemic organ dysfunction can influence the brain's response to injury and recovery.
  • Bidirectional communication pathways between the brain and periphery are implicated.

Conclusions:

  • TBI initiates complex systemic responses that interact with the central nervous system.
  • Understanding these interactions is crucial for improving TBI patient outcomes.
  • Further research into underlying mechanisms may reveal novel therapeutic targets.