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Mining Helminths for Novel Therapeutics.

Katherine E Lothstein¹, William C Gause¹

¹Center for Immunity and Inflammation, Department of Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA.

Trends in Molecular Medicine

|January 26, 2021

Summary

Helminth excretory/secretory (ES) molecules show therapeutic potential for inflammatory diseases by modulating immune responses. These parasite-derived molecules offer novel strategies for treating immune dysregulation.

Keywords:

Tregs excretory/secretory helminths inflammatory diseases therapeutics type 2 immune response

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Area of Science:

Immunology
Parasitology
Pharmacology

Background:

Helminths are increasingly recognized as a source of novel therapeutics.
Excretory/secretory (ES) molecules from helminths possess significant immunomodulatory properties.
These molecules are crucial for parasite survival and host immune evasion.

Purpose of the Study:

To review recent findings on helminth ES molecule modulation of immune functions.
To highlight the therapeutic potential of ES molecules in inflammatory diseases.
To discuss the clinical implications for future anti-inflammatory therapies.

Main Methods:

Literature review of studies on helminth ES molecules and immune responses.
Analysis of research on ES molecule mechanisms targeting immune pathways.
Examination of therapeutic applications in preclinical inflammatory disease models.

Main Results:

ES molecules effectively modulate both type 1 and type 2 immune responses.
Evidence supports the targeting of various immune response pathways by ES molecules.
Studies demonstrate promising therapeutic effects in specific inflammatory disease models.

Conclusions:

Helminth ES molecules represent a promising therapeutic avenue for inflammatory diseases.
Further research into ES molecule mechanisms can unlock their full clinical potential.
These molecules offer a novel strategy for managing immune dysregulation.