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Updated: Nov 20, 2025

Experimental Endocarditis Model of Methicillin Resistant Staphylococcus aureus MRSA in Rat
Published on: June 4, 2012
Prosthetic valve endocarditis caused by silent infection of methicillin-resistant coagulase-negative staphylococci
Kayo Sugiyama1, Hirotaka Watanuki2, Yasuhiro Futamura2
1Department of Cardiac Surgery, Aichi Medical University, Nagakute, Aichi, Japan kayotaro3@gmail.com.
Abstract:
Surgery for prosthetic valve endocarditis in the mitral valve position is still challenging for surgeons. Reconstruction of the mitral annulus is useful for patients with a mitral annulus disputed by infection. Here, we report a redo mitral valve replacement using a collar-reinforced tissue valve, which was inserted into a mitral annulus reconstructed with a bovine patch. Though the preoperative blood culture detected Streptococcus anginosus, the intraoperative culture detected methicillin-resistant coagulase-negative staphylococci (MRCNS). MRCNS is rarely detected because of its indolent nature.
Insights
This study details a complex redo mitral valve replacement for prosthetic valve endocarditis, successfully using a reconstructed mitral annulus and a reinforced tissue valve. The findings highlight the challenge of detecting indolent methicillin-resistant coagulase-negative staphylococci (MRCNS) in such cases.
Area of Science:
- Cardiovascular Surgery
- Infectious Diseases
- Biomaterials in Medicine
Background:
- Prosthetic valve endocarditis in the mitral position presents significant surgical challenges.
- Mitral annulus reconstruction is a viable option for infected annuli.
Observation:
- A redo mitral valve replacement was performed using a collar-reinforced tissue valve.
- The mitral annulus was reconstructed with a bovine patch.
- Preoperative cultures identified Streptococcus anginosus, while intraoperative cultures revealed methicillin-resistant coagulase-negative staphylococci (MRCNS).
Findings:
- Successful implantation of a reinforced tissue valve into a reconstructed mitral annulus.
- The identification of MRCNS, an organism rarely detected due to its indolent nature, highlights diagnostic challenges.
Implications:
- This case demonstrates a successful surgical strategy for complex prosthetic valve endocarditis.
- Improved diagnostic methods for indolent pathogens like MRCNS are needed.
- Bovine pericardial patches are effective for mitral annulus reconstruction in challenging cases.
Related Concept Videos
Endocarditis I: Introduction
Endocarditis III: Medical Management
Mitral Stenosis I: Introduction
Endocarditis II: Clinical Features of Infective Endocarditis
Mitral Stenosis III: Medical Management
Endocarditis IV: Nursing Management

