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Sepsis-Associated Encephalopathy: from Pathophysiology to Progress in Experimental Studies.
Anderson Velasque Catarina1, Gisele Branchini2, Lais Bettoni2
1Programa de Pós-graduação em Patologia, Universidade Federal de Ciências da Saúde de Porto Alegre - UFCSPA, Porto Alegre, RS, 90050-170, Brazil. anderson.catarina@acad.pucrs.br.
Molecular Neurobiology
|January 26, 2021
Summary
Sepsis-associated encephalopathy (SAE) is brain dysfunction from uncontrolled inflammation during sepsis. Understanding SAE
Area of Science:
- Neuroscience
- Critical Care Medicine
- Pathophysiology
Background:
- Sepsis causes organ dysfunction, with the brain being highly vulnerable.
- Sepsis-associated encephalopathy (SAE) affects up to 70% of ICU patients.
- SAE involves complex inflammatory and oxidative damage to the central nervous system (CNS).
Purpose of the Study:
- To summarize SAE pathophysiology and identify current experimental therapeutic targets.
- To highlight the need for better understanding and treatment of SAE.
- To review advances in experimental studies for SAE treatment.
Main Methods:
- This is a review article.
- It synthesizes information on SAE pathophysiology.
- It focuses on current experimental therapeutic strategies.
Main Results:
- SAE pathophysiology is multifactorial, involving inflammation, neuroinflammation, oxidative stress, and blood-brain barrier (BBB) disruption.
- Current treatments for SAE are limited due to incomplete understanding of its causes.
- Experimental studies are exploring new therapeutic avenues.
Conclusions:
- SAE is a complex condition with significant impact on sepsis patients.
- Further research into SAE pathophysiology is crucial for developing effective treatments.
- Advances in experimental therapies offer hope for reducing SAE's effects.
