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Updated: Nov 20, 2025

Resin-Assisted Capture Coupled with Isobaric Tandem Mass Tag Labeling for Multiplexed Quantification of Protein Thiol Oxidation
Published on: June 21, 2021
Proton Transfer and SN 2 Reactions as Steps of Fast Selenol and Thiol Oxidation in Proteins: A Model Molecular Study
Marco Dalla Tiezza1, F Matthias Bickelhaupt2,3, Leopold Flohé4,5
1Dipartimento di Scienze Chimiche, Università degli Studi di Padova, Via Marzolo 1, 35131, Padova, Italy.
Abstract:
Invited for this month's cover are collaborating groups from Università degli Studi di Padova, Vrije Universiteit Amsterdam, and Universidad de la República Uruguay. The cover picture shows two lorries along the road directed to the destination 'H2 O2 reduction', and the selenol (SeH) lorry is faster than the thiol (SH) lorry. This cartoon represents the situation of glutathione peroxidase (GPx), in which the presence of selenium rather than sulfur warrants a significantly faster hydroperoxide reduction along the same mechanistic path. Read the full text of the article at 10.1002/cplu.202000660.
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