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Related Experiment Videos

Papillary muscle structure-function relations in the aging spontaneously hypertensive rat.

O H Bing1, A W Wiegner, W W Brooks

  • 1Boston VA Medical Center, Massachusetts 02130.

Clinical and Experimental Hypertension. Part A, Theory and Practice
|January 1, 1988
PubMed
Summary

Spontaneously hypertensive rats (SHR) showed increased papillary muscle tension normalized by muscle area, but not myofibrillar area. Isolated muscle function was not depressed in SHR compared to controls at any age.

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Area of Science:

  • Cardiovascular Physiology
  • Muscle Mechanics
  • Hypertension Research

Background:

  • Spontaneously hypertensive rats (SHR) are a common model for studying hypertension.
  • Papillary muscle dysfunction can contribute to heart failure in hypertensive states.
  • Understanding cellular and subcellular mechanics is crucial for elucidating cardiac performance changes.

Purpose of the Study:

  • To investigate the mechanics and structure of isolated left ventricle papillary muscles in male SHR.
  • To compare muscle performance in SHR with normotensive control rats (NR and WKY) across different ages.
  • To determine if observed mechanical differences are due to intrinsic muscle properties or altered cellular structure.

Main Methods:

  • Isolated left ventricle papillary muscle preparations from male SHR, NR, and WKY rats.

Related Experiment Videos

  • Measurement of active tension and its first derivative (dT/dtmax).
  • Normalization of mechanical parameters by both muscle cross-sectional area and myofibrillar cross-sectional area (electron microscopy).
  • Assessment of force-velocity relations and duration of mechanical activity.

    • Main Results:

    • Active tension and dT/dtmax normalized for muscle area were significantly increased in SHR compared to controls (P < 0.01).
    • These differences became non-significant when normalized for myofibrillar cross-sectional area.
    • No depression of shortening velocity was observed in SHR at any age or load.
    • Prolonged mechanical activity duration was noted only in 18-month-old SHR (P < 0.01).

    Conclusions:

    • Apparent increases in papillary muscle tension in SHR are likely due to increased myofibrillar content per muscle area, not intrinsic functional depression.
    • Isolated papillary muscle function is not depressed in SHR at 6, 12, or 18 months of age.
    • Mechanical changes in SHR papillary muscles do not explain hemodynamic impairment observed in the intact animal at 18 months.