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Published on: August 9, 2019
Hydrated Rubrolides from the New Zealand Tunicate Synoicum kuranui
Joe Bracegirdle1, Luke J Stevenson1, Abigail V Sharrock1
1Maurice Wilkins Centre for Molecular Biodiscovery, Auckland 1142, New Zealand.
Abstract:
LCMS analysis of an extract of the New Zealand tunicate Synoicum kuranui showed evidence for numerous new rubrolides. Following a mass spectrometry-guided isolation procedure, new hydrated rubrolides V and W (5 and 6), along with previously reported rubrolide G (3), were isolated and characterized using MS and NMR. The anti-bacterial and cell cytotoxic activity of the compounds were compared to the potent anti-MRSA compound rubrolide A; hydration across the C-5/C-6 bond was shown to abrogate antibacterial activity.
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