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Stereotactic Adoptive Transfer of Cytotoxic Immune Cells in Murine Models of Orthotopic Human Glioblastoma Multiforme Xenografts
Published on: September 1, 2018
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Current Advances in Immunotherapy for Glioblastoma
Abigail L Mende1, Jessica D Schulte1,2, Hideho Okada3,4,5
1Department of Neurological Surgery, University of California, Diller Family Cancer Research Building HD 472, Box 520, 1450 3rd Street San Francisco, Helen, CA, 94158, USA.
Current Oncology Reports
|January 26, 2021
Summary
Novel immunotherapies show promise for glioblastoma treatment. This review details clinical trials and strategies to overcome challenges in the central nervous system for improved glioblastoma immunotherapy.
Area of Science:
- Neuro-oncology
- Immunology
- Cancer Therapy
Background:
- Glioblastoma (GBM) exhibits limited response to conventional treatments.
- Immunotherapy success in other cancers motivates GBM research.
- GBM's complexity includes tumor heterogeneity and immune evasion.
Purpose of the Study:
- To review novel immunotherapies for glioblastoma (GBM).
- To discuss clinical trials and technologies addressing CNS-specific challenges.
- To inform clinicians and researchers on GBM immunotherapy advancements.
Main Methods:
- Review of ongoing and completed clinical trials.
- Analysis of technologies overcoming CNS immune barriers.
- Discussion of immunotherapeutic strategies including vaccines, checkpoint inhibitors, and oncolytic viruses.
Main Results:
- Glioblastoma presents unique challenges: immune barriers, impaired antigen presentation, T cell dysfunction.
- Multi-antigen vaccines and immune checkpoint inhibitors are being explored.
- Oncolytic viruses offer combinatorial treatment potential.
- GBM's resistance necessitates multimodal treatment regimens.
Conclusions:
- Glioblastoma immunotherapy faces significant hurdles.
- Novel approaches like combination therapies are crucial.
- Further research is needed to overcome GBM's resistance to immune-mediated therapies.
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