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Application of Long-term cultured Interferon-γ Enzyme-linked Immunospot Assay for Assessing Effector and Memory T Cell Responses in Cattle
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Late acting T cell depression of high avidity IgG antibody secretion in the secondary response

R W Warren, J M Davie

    Journal of Immunology (Baltimore, Md. : 1950)
    |November 1, 1977
    PubMed

    Activated T lymphocytes (ATC) suppressed the expression of high avidity plaque-forming cells (PFC) in the secondary immune response when given in vivo 1 day before assay or when mixed in vitro with hyperimmune cells for 90 min before assay. This late acting suppression is a cell dose-dependent, carrier-spedific, T cell-mediated phenomenon. The target of this activity if probably the antibody-secreting cell.

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