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Updated: Nov 20, 2025

Harmonic Nanoparticles for Regenerative Research
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Hybrid Nanosystems for Biomedical Applications.

Joshua Seaberg1, Hossein Montazerian2,3,4, Md Nazir Hossen1,5

  • 1Department of Pathology, University of Oklahoma Health Science Center, Oklahoma City, Oklahoma 73104, United States.

ACS Nano
|January 26, 2021
PubMed
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Hybrid nanosystems combine inorganic and organic materials for advanced biomedical applications like drug delivery and imaging. This review details their development, classification, and future potential in medicine.

Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Nanotechnology

Background:

  • Inorganic/organic hybrid nanosystems offer unique advantages over traditional materials.
  • These systems are increasingly utilized across diverse biomedical fields, including therapeutics and diagnostics.

Purpose of the Study:

  • To provide a comprehensive review of inorganic/organic hybrid nanosystems in biomedicine.
  • To classify these nanosystems based on their components and hybridization architecture.
  • To highlight recent innovations and applications, and discuss future prospects.

Main Methods:

  • Historical overview of biomedical hybrid nanosystem development.
  • Description of component building blocks: properties, synthesis, and characterization.
Keywords:
biomedical nanosystemsbiomolecular sensorsdrug deliverygene therapyhybrid nanoparticlehybrid nanosysteminorganic/organic hybridizationnanomaterialsphototherapytheranostics

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  • Analysis of hybridization architectures and application-specific advancements.

    • Main Results:

    • Hybrid nanosystems are classified by inorganic/organic components, accessory moieties, and hybridization architecture.
    • Diverse applications include gene therapy, drug delivery, phototherapy, tissue regeneration, vaccines, antibacterials, biomolecule detection, imaging, and theranostics.
    • Emphasis on innovative hybrids with distinctive utility and ongoing clinical trial developments.

    Conclusions:

    • Inorganic/organic hybrid nanosystems represent a versatile platform for addressing complex biomedical challenges.
    • Continued innovation in design, synthesis, and application is driving the field forward.
    • The future trajectory suggests expanded clinical translation and novel therapeutic strategies.