Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Therapy00:59

Gene Therapy

26.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
26.7K
What is Genetic Engineering?00:49

What is Genetic Engineering?

77.2K
Overview
77.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

8.1K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.1K
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

5.6K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
5.6K
Genetic Screens02:46

Genetic Screens

5.3K
Genetic screens are tools used to identify genes and mutations responsible for phenotypes of interest. Genetic screens help identify individuals or a group of people at risk of developing  genetic diseases and help them with early intervention, targeted therapy, and reproductive options.
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which...
5.3K
Human Genetics01:28

Human Genetics

1.1K
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
1.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Harmonizing standards and resources for the medical genome.

Nature·2026
Same author

Segmentation-free analysis of live-cell imaging data reveals how T cell modifications influence cancer cell aggregation dynamics.

Scientific reports·2026
Same author

Host Genetic Regulation of NLRP3 Inflammasome Cytokines Reveals Immune and Vascular Pathways in HIV.

medRxiv : the preprint server for health sciences·2026
Same author

Activation-induced SLC7A1 expression enhances T cell sensitivity to cGAMP-mediated STING signaling.

Cell reports·2026
Same author

Development of a Fully Non-Viral 1XX-enhanced BCMA CAR-T Cell Therapy for Multiple Myeloma.

bioRxiv : the preprint server for biology·2026
Same author

Systematic discovery of pro- and anti-HIV host factors in primary human CD4+ T cells.

Cell·2026
Same journal

Basic Microglial Functions and How They Go Awry in Neurodegenerative Disease.

Annual review of pathology·2026
Same journal

Integration and Intersection of Cancer Metabolism with Epigenetic Pathways in Gliomas.

Annual review of pathology·2025
Same journal

The Role of Fibroblasts Across Inflammation and Immunity.

Annual review of pathology·2025
Same journal

The Role of MicroRNAs in Viral and Bacterial Infections.

Annual review of pathology·2025
Same journal

Role of Immune Cells in Hepatitis B Virus and Associated Sequelae.

Annual review of pathology·2025
Same journal

Pathology of the Coronary Arteries and Myocardium in Kawasaki Disease.

Annual review of pathology·2025
See all related articles

Related Experiment Video

Updated: Nov 20, 2025

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

2.0K

Genetic Disease and Therapy.

Theodore L Roth1,2,3,4, Alexander Marson2,3,4,5,6,7,8

  • 1Medical Scientist Training Program, University of California, San Francisco, California 94143, USA;

Annual Review of Pathology
|January 26, 2021
PubMed
Summary
This summary is machine-generated.

Genetic diseases stem from mitochondrial, nuclear, and microbial DNA. Next-generation sequencing aids diagnosis, while gene editing offers targeted therapies for these complex conditions.

Keywords:
clinical geneticsgene editinggene therapiesgenetic diagnosticsgenetic disease

More Related Videos

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System
07:04

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System

Published on: February 4, 2021

2.3K
In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

21.0K

Related Experiment Videos

Last Updated: Nov 20, 2025

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
09:37

Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells

Published on: August 25, 2021

2.0K
Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System
07:04

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System

Published on: February 4, 2021

2.3K
In Vivo Modeling of the Morbid Human Genome using Danio rerio
12:31

In Vivo Modeling of the Morbid Human Genome using Danio rerio

Published on: August 24, 2013

21.0K

Area of Science:

  • Genetics and Genomics
  • Molecular Biology
  • Biotechnology

Background:

  • Genetic diseases present complex and challenging pathologies.
  • The mitochondrial genome, nuclear genome, and microbial metagenome contain DNA sequences linked to human complexity and disease risks.
  • Next-generation DNA sequencing has become a unified diagnostic approach for these diseases.

Purpose of the Study:

  • To review the current landscape of genetic diagnostics and therapies.
  • To discuss the structure and variability of key human genetic compartments.
  • To highlight the progression towards targeted genetic therapies.

Main Methods:

  • Review of historical development and current practices in genetic diagnostics.
  • Analysis of existing genetic therapy categories: genome replacement, genetic material addition, and gene editing.
  • Discussion of reagent delivery methods for different genetic compartments.

Main Results:

  • Genetic diagnostics have largely converged on next-generation sequencing.
  • Genetic therapies have evolved from broad replacement to precise gene editing.
  • Generalized methods for diagnosis, therapy, and delivery are crucial for future advancements.

Conclusions:

  • Targeted genetic therapies are a central goal in treating genetic diseases.
  • Advancements in diagnosing and treating mitochondrial, nuclear, and microbial genetic alterations are critical.
  • Developing generalized approaches for genetic diagnosis and therapy will accelerate curative treatments.