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A body-mounted device for MRI-guided spinal therapy.

Alexander Squires1, Sierra Hovet1, Rui Li2

  • 1School of Electrical and Computer Engineering, University of Georgia, Athens, Georgia, USA.

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A new robotic system simplifies MRI-guided spinal cord injections for treating neurodegenerative diseases like Amyotrophic Lateral Sclerosis (ALS). This technology improves targeting accuracy and streamlines therapeutic delivery to the spinal cord.

Keywords:
MRI-guided therapyamyotrophic lateral sclerosisspine

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Area of Science:

  • Biomedical Engineering
  • Neuroscience
  • Robotics

Background:

  • Amyotrophic Lateral Sclerosis (ALS) is a progressive neurodegenerative disorder with no cure.
  • Cellular therapeutics show promise for halting ALS progression when delivered to the spinal cord's ventral horn.
  • Current delivery methods for spinal cord therapies require refinement for precision and efficiency.

Purpose of the Study:

  • To develop and evaluate a robotic system for precise, MRI-guided percutaneous injections into the spinal cord.
  • To assess the accuracy and workflow efficiency of the robotic system for potential ALS cellular therapy delivery.

Main Methods:

  • A novel robotic system was engineered for MRI-guided needle placement.
  • The robot incorporates motorized sleds for 2-DOF needle translation and a radial template for 2-DOF rotation.
  • System performance was validated using phantom models and swine cadavers.

Main Results:

  • The robotic system achieved mean targeting errors of 0.48 mm in phantoms and 2.84 mm in swine cadavers.
  • The targeting procedure duration averaged 60 minutes, with an additional 10 minutes per subsequent injection.
  • The robot demonstrated no adverse impact on MRI imaging quality.

Conclusions:

  • The developed robotic system facilitates a simplified workflow for MRI-guided spinal therapies.
  • This technology offers enhanced precision for delivering cellular therapeutics to the spinal cord.
  • The system holds potential for advancing treatments for neurodegenerative diseases like ALS.