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Related Experiment Videos

Angiotensin II attenuates reflex decrease in heart rate and sympathetic activity in man.

K Sander-Jensen1, N H Secher, A Astrup

  • 1Department of Medical Physiology C, Panum Institute, University of Copenhagen, Denmark.

Clinical Physiology (Oxford, England)
|February 1, 1988
PubMed
Summary
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Physiological doses of angiotensin II (ANG II) in humans increase blood pressure and aldosterone but do not affect heart rate or catecholamines. ANG II also reduces subcutaneous blood flow, indicating augmented sympathetic activity.

Area of Science:

  • Cardiovascular Physiology
  • Endocrinology
  • Renal Physiology

Background:

  • Angiotensin II (ANG II) plays a crucial role in regulating blood pressure and fluid balance.
  • Understanding the precise effects of physiological ANG II levels on human circulation is essential for managing cardiovascular health.

Purpose of the Study:

  • To investigate the circulatory and hormonal responses to physiological infusions of Angiotensin II in normal human subjects.
  • To determine the impact of ANG II on sympathetic and vagal activity, as well as hormone release.

Main Methods:

  • Six healthy subjects received step-up infusions of Angiotensin II (ANG II) at 0.25 and 1.00 ng kg-1 X min.
  • Circulatory variables (mean arterial pressure, heart rate) and plasma hormone concentrations (aldosterone, vasopressin, catecholamines, pancreatic polypeptide) were measured.

Related Experiment Videos

Main Results:

  • ANG II infusion increased mean arterial pressure and plasma aldosterone levels.
  • Plasma concentrations of ANG II reached levels comparable to those during acute hypotensive hypovolemia.
  • Subcutaneous blood flow decreased, suggesting augmented sympathetic activity, while heart rate and catecholamines remained unchanged.
  • Vasopressin, adrenalin, and pancreatic polypeptide levels did not significantly change.

Conclusions:

  • Physiological doses of ANG II in humans may enhance sympathetic activity, as evidenced by increased blood pressure without compensatory heart rate or catecholamine changes.
  • ANG II does not appear to broadly suppress vagal tone.
  • The tested ANG II concentrations do not stimulate vasopressin release.
  • A reduction in subcutaneous blood flow occurs at relatively low increases in plasma ANG II concentrations.