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Sensitization to patch test acrylates.

L Kanerva1, T Estlander, R Jolanki

  • 1Section of Dermatology, Institute of Occupational Health, Helsinki, Finland.

Contact Dermatitis
|January 1, 1988
PubMed
Summary
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Allergic contact dermatitis from acrylates is a concern, with new sensitizations identified in patch testing. Lowering acrylate concentrations in testing may be necessary to prevent harmful reactions.

Area of Science:

  • Dermatology
  • Allergology
  • Toxicology

Background:

  • Acrylate exposure can cause allergic contact dermatitis.
  • Routine patch testing is crucial for identifying allergens.

Purpose of the Study:

  • To report cases of allergic contact dermatitis from acrylates.
  • To evaluate the sensitization potential of different acrylates during patch testing.

Main Methods:

  • Patch testing with various acrylates between 1982-1985.
  • Utilizing a commercial (meth)acrylate series since September 1985.
  • Adjusting test concentrations based on observed sensitization.

Main Results:

  • One out of 22 patients (4.5%) was sensitized to ethyl acrylate and butyl acrylate (1% pet.) during 1982-1985.

Related Experiment Videos

  • Three out of 24 patients became sensitized to ethyl acrylate, 2-hydroxyethyl acrylate, and 2-hydroxypropyl acrylate (0.5% pet.) since September 1985.
  • Current testing uses ethyl acrylate, 2-hydroxyethyl acrylate, and 2-hydroxypropyl acrylate at 0.167% pet.

    • Conclusions:

    • Active sensitization to acrylates can be harmful.
    • Lowering acrylate concentrations in patch testing may be required.
    • Ongoing monitoring and adjustment of testing protocols are essential.