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New perspectives in oral peptide delivery
Alessandra T Zizzari1, Dimanthi Pliatsika1, Flavio M Gall1
1Center of Organic and Medicinal Chemistry, Institute of Chemistry and Biotechnology, Zurich University of Applied Sciences ZHAW, Einsiedlerstrasse 31, 8820 Wädenswil, Switzerland.
Drug Discovery Today
|January 26, 2021
Summary
Peptide drugs offer diverse therapeutic potential but face challenges with oral delivery. This review explores recent advancements in improving peptide oral bioavailability, paving the way for more effective and safer peptide therapeutics.
Area of Science:
- Pharmaceutical Sciences
- Medicinal Chemistry
- Drug Delivery
Background:
- Peptides possess significant structural diversity, making them valuable sources for novel active pharmaceutical ingredients.
- Development of peptide-based drugs is hindered by poor pharmacokinetic (PK) properties, particularly low oral bioavailability.
- Improving oral delivery of peptides is a critical unmet need in drug development.
Purpose of the Study:
- To review and highlight recent innovative techniques for enhancing the oral bioavailability of peptide drugs.
- To provide insights into the latest findings that can guide future pharmaceutical research and development strategies.
- To discuss the potential impact of improved oral peptide delivery on creating more efficient and safer therapeutic options.
Main Methods:
- Comprehensive literature review of recent scientific publications and patents.
- Analysis of emerging technologies and strategies focused on peptide oral absorption.
- Synthesis of information on the efficacy and challenges of different bioavailability enhancement approaches.
Main Results:
- Several promising techniques have emerged to overcome the pharmacokinetic limitations of peptides.
- Recent advancements include novel formulation strategies, chemical modifications, and delivery systems.
- These innovations show potential for significantly increasing the oral absorption of peptide therapeutics.
Conclusions:
- The structural diversity of peptides makes them attractive drug candidates, but PK challenges remain.
- Recent technological advancements offer viable solutions for improving oral peptide bioavailability.
- Future pharmaceutical development will likely focus on these advanced strategies for orally administered peptide drugs, enhancing efficacy and safety.
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