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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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Related Experiment Video

Updated: Nov 19, 2025

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
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Selenium Compounds as Novel Potential Anticancer Agents.

Dominika Radomska1, Robert Czarnomysy1, Dominik Radomski1

  • 1Department of Synthesis and Technology of Drugs, Medical University of Bialystok, Jana Kilinskiego 1, 15-089 Bialystok, Poland.

International Journal of Molecular Sciences
|January 27, 2021
PubMed
Summary

Selenium compounds show promise in fighting existing cancers. This review explores various selenium-containing molecules, their anticancer mechanisms, and molecular targets for new cancer therapies.

Keywords:
anticancer agentscancerchemopreventioncombinatorial therapydrug resistancemolecular targetselenium compounds

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Area of Science:

  • Oncology
  • Medicinal Chemistry
  • Biochemistry

Background:

  • Cancer incidence and mortality remain significant global health concerns.
  • Existing cancer therapies can be burdensome for patients, necessitating the search for novel treatments.
  • Selenium (Se) compounds have demonstrated chemopreventive properties, prompting investigation into their efficacy against established cancers.

Purpose of the Study:

  • To review and discuss the anticancer activities of various classes of selenium-containing compounds.
  • To elucidate the mechanisms of action and molecular targets of these selenium compounds in cancer treatment.
  • To explore both inorganic and organic selenium compounds, including natural and synthetic derivatives.

Main Methods:

  • Literature review of studies on selenium compounds and their anticancer effects.
  • Categorization of selenium compounds into inorganic (selenite, selenate) and various organic classes.
  • Analysis of documented mechanisms and molecular targets associated with anticancer activity.

Main Results:

  • Diverse classes of selenium compounds, including diselenides, selenides, selenoesters, methylseleninic acid, 1,2-benzisoselenazole-3[2H]-one, selenophene derivatives, selenoamino acids, and Selol, exhibit anticancer potential.
  • These compounds act through various mechanisms to target cancer cells.
  • Evidence suggests selenium's role extends beyond prevention to impacting existing malignancies.

Conclusions:

  • Selenium compounds represent a promising area for developing new, less burdensome cancer therapies.
  • Understanding the diverse mechanisms and molecular targets is crucial for optimizing selenium-based anticancer strategies.
  • Further research into these compounds could lead to novel therapeutic agents for various cancers.