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Related Experiment Video

Updated: Nov 19, 2025

Synthesis of Core-shell Lanthanide-doped Upconversion Nanocrystals for Cellular Applications
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Engineering Red-Enhanced and Biocompatible Upconversion Nanoparticles.

Masfer Alkahtani1,2, Najla Alsofyani1, Anfal Alfahd1

  • 1King Abdulaziz City for Science and Technology (KACST), Riyadh 11442, Saudi Arabia.

Nanomaterials (Basel, Switzerland)
|January 27, 2021
PubMed
Summary
This summary is machine-generated.

We engineered bright, small lanthanide-doped upconversion nanoparticles (UCNPs) with a core-shell-shell structure. These non-toxic UCNPs offer enhanced fluorescence in biological windows for advanced bioapplications.

Keywords:
bioapplicationbioimagingred-enhanced fluorescent markersupconversion nanoparticles

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Area of Science:

  • Nanotechnology
  • Materials Science
  • Biomedical Engineering

Background:

  • Lanthanide-doped upconversion nanoparticles (UCNPs) possess unique optical properties, making them valuable fluorescent markers for bioapplications.
  • Improving UCNP brightness and reducing size are crucial for effective use in biological systems.
  • Surface quenching effects can significantly reduce UCNP luminescence, necessitating strategies like inert shell addition.

Purpose of the Study:

  • To engineer bright and small core-shell-shell (CSS) UCNPs.
  • To enhance UCNP emission within the biological transparency window using biocompatible excitation wavelengths.
  • To evaluate the biosafety of the synthesized CSS UCNPs in living cell models.

Main Methods:

  • Synthesis of CSS UCNPs with optimized lanthanide dopant concentrations.
  • Characterization of UCNP optical properties, focusing on emission enhancement.
  • Investigation of CSS UCNP biosafety using in vitro living cell models.

Main Results:

  • Successfully engineered bright and small CSS UCNPs.
  • Achieved enhanced UCNP emission in the biological transparency window.
  • Demonstrated the biosafety of the synthesized CSS UCNPs in living cells.

Conclusions:

  • The developed CSS UCNPs exhibit superior brightness and small size, suitable for bioimaging.
  • Optimized dopant concentrations and CSS structure enhance UCNP performance in biological environments.
  • These bright and non-toxic UCNPs show significant promise as fluorescent probes for bioapplications.