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Related Experiment Videos

Absorption of intraperitoneal antibiotics.

G D Morse1, M A Apicella, J J Walshe

  • 1Department of Pharmacy, State University of New York, Buffalo.

Drug Intelligence & Clinical Pharmacy
|January 1, 1988
PubMed
Summary

Antibiotic absorption from peritoneal dialysis fluid is faster in patients with peritonitis. This study compared vancomycin and cefamandole absorption in continuous ambulatory peritoneal dialysis (CAPD) patients with and without peritonitis.

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Area of Science:

  • Nephrology
  • Pharmacology
  • Infectious Diseases

Background:

  • Continuous ambulatory peritoneal dialysis (CAPD) patients with peritonitis typically receive intraperitoneal (ip) antibiotics.
  • Understanding ip antibiotic absorption is crucial for effective peritonitis treatment in CAPD.

Purpose of the Study:

  • To investigate the absorption kinetics of common intraperitoneal antibiotics in CAPD patients.
  • To compare antibiotic absorption in CAPD patients with and without peritonitis.

Main Methods:

  • Evaluated ip administration of tobramycin, vancomycin, cefamandole, and moxalactam in noninfected CAPD patients.
  • Administered vancomycin or cefamandole via ip route to CAPD patients with peritonitis over a six-hour dwell period.

Main Results:

  • Vancomycin and cefamandole showed more rapid absorption in peritonitis patients, evidenced by faster dialysate concentration decline and earlier, higher serum levels.
  • Despite increased absorption percentage, peak serum concentrations of vancomycin and cefamandole were not significantly different between infected and noninfected groups at dwell period's end.
  • Factors such as dialysate concentration, dwell time, protein binding, and distribution volume influence ip antibiotic absorption.

Conclusions:

  • Peritonitis significantly alters the absorption of intraperitoneal antibiotics like vancomycin and cefamandole in CAPD patients.
  • The presence of peritonitis enhances the rate of antibiotic absorption from the peritoneal cavity.
  • Further research is needed to optimize antibiotic dosing strategies in CAPD-associated peritonitis.

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