Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

565
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
565
Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

17.4K
A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
17.4K
Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

14.9K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
14.9K
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

634
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
634
Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

306
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
306
Peptic Ulcer Disease I: Introduction01:30

Peptic Ulcer Disease I: Introduction

473
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
473

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Expression and Characterization of a Recombinant Laccase with Alkalistable and Thermostable Properties from Streptomyces griseorubens JSD-1.

Applied biochemistry and biotechnology·2015
Same author

Herb-Partitioned Moxibustion and the miRNAs Related to Crohn's Disease: A Study Based on Rat Models.

Evidence-based complementary and alternative medicine : eCAM·2015
Same author

Bioactive carbazole alkaloids from the stems of Clausena lansium.

Fitoterapia·2015
Same author

Clauemarazoles A-G, seven carbazole alkaloids from the stems of Clausena emarginata.

Fitoterapia·2015
Same author

Scalable and DiI-compatible optical clearance of the mammalian brain.

Frontiers in neuroanatomy·2015
Same author

FSH regulates fat accumulation and redistribution in aging through the Gαi/Ca(2+)/CREB pathway.

Aging cell·2015

Related Experiment Video

Updated: Nov 19, 2025

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

983

STAT6 rs324015 Gene Polymorphism Increases Ulcerative Colitis Risk: A Case-Control Study.

Lingying Dai1, Dan Zhang2, Yunzhi Qian2

  • 1No. 1 Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, People's Republic of China.

Pharmacogenomics and Personalized Medicine
|January 27, 2021
PubMed
Summary

The STAT6 rs324015 polymorphism increases the risk of ulcerative colitis (UC), particularly in younger, alcohol-using, or smoking individuals. This genetic factor is linked to UC severity and location in the Chinese Han population.

Keywords:
STAT6case–control studyrs324015 polymorphismulcerative colitis

More Related Videos

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.4K
Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.4K

Related Experiment Videos

Last Updated: Nov 19, 2025

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer
06:21

Author Spotlight: Genetic Profiling for Fluorouracil Response in Gastric Cancer

Published on: May 10, 2024

983
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.4K
Chronic Salmonella Infection Induced Intestinal Fibrosis
08:40

Chronic Salmonella Infection Induced Intestinal Fibrosis

Published on: September 22, 2019

7.4K

Area of Science:

  • Genetics
  • Gastroenterology
  • Molecular Biology

Background:

  • Signal transducer and activator of transcription 6 (STAT6) phosphorylation is elevated in ulcerative colitis (UC) patients.
  • STAT6 inhibition mitigates IL-13-induced apoptosis and barrier disruption in the colon.
  • The STAT6 rs324015 polymorphism has been implicated in genetic susceptibility to UC.

Purpose of the Study:

  • To investigate the association between the STAT6 rs324015 polymorphism and UC risk.
  • To explore gene-environment interactions related to UC.
  • To determine the correlation of this polymorphism with UC severity and location.

Main Methods:

  • Genotyping of STAT6 rs324015 was performed using PCR-RFLP in 268 UC cases and 357 controls.
  • STAT6 gene expression levels were quantified using reverse-transcription PCR.
  • Gene-environment interactions were analyzed through cross-over analysis.

Main Results:

  • The STAT6 rs324015 polymorphism was significantly associated with an increased risk of UC across homozygous, dominant, and allelic models.
  • Subgroup analyses revealed a stronger association in alcohol users, smokers, and individuals under 40.
  • Interactions between STAT6 rs324015 and smoking/alcohol use were identified, along with associations with UC severity and location. The GG genotype correlated with higher STAT6 expression.

Conclusions:

  • The STAT6 rs324015 polymorphism is a significant genetic factor predisposing individuals to ulcerative colitis in the Chinese Han population.
  • Environmental factors like smoking and alcohol use interact with this polymorphism, influencing UC risk and characteristics.