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Hydrocortisone differentially alters lesion-induced axon sprouting in male and female rats
S W Scheff1, J K Morse, S T DeKosky
1Department of Anatomy, Sanders-Brown Research Center on Aging, University of Kentucky, Lexington.
Experimental Neurology
|April 1, 1988
Abstract:
Hydrocortisone was administered to young adult male or female rats after removal of the entorhinal cortex. Lesion-induced outgrowth of the commissural-associational afferent fibers in the hippocampus was quantitated. The glucocorticoids caused a significant decline in axon sprouting in the male subjects and a significant increase in outgrowth in female subjects. Depending on the sex, the hormonal effects on lesion-induced axonal growth are markedly different in the rat.