Related Experiment Videos
Endogenous inhibitor of ecdysone synthesis in crabs
Y Naya1, K Kishida, M Sugiyama
1Suntory Institute for Bioorganic Research, Osaka, Japan.
Experientia
|January 15, 1988
Abstract:
Attempts to isolate the molt-inhibiting hormone (MIH) of crustaceans from crab eyestalks (ES) resulted in the characterization of xanthurenic acid as an inhibitor of ecdysone biosynthesis in the cultured Y-organ-complex (YOC) homogenate. It was also found that 3-hydroxy-L-kynurenine present in the ES is transformed into xanthurenic acid in the YOC and body fluid. Its mode of inhibitory action in ecdysone biosynthesis is probably inactivation of cytochrome P-450.