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Steroid hormones enhanced sister-chromatid exchange in cultured CHO cells
1Division of Mathematics and Sciences, Kentucky State Univesity, Frankfort 40601.
Experientia
|January 15, 1988
Abstract:
The influence of steroid hormones on the induction of sister-chromatid exchange (SCE) in cultured CHO cells was studied. It was observed that estradiol-17 beta, estriol, estrone and ethynyl estradiol treatments enhanced SCE rates compared to the controls. Overall, these compounds produced a dose response effect. The importance of a detailed study on the long-term genetic effects of steroids on mammalian cells is emphasized.