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Updated: Nov 19, 2025

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Compensated hypogonadism in men with sickle cell disease
Anna Paloma M R Ribeiro1, Caroline S Silva1, Jean Carlos C Zambrano1
1Division of Public Health, Department of Health, State University of Feira de Santana, Feira de Santana, Bahia, Brazil.
Compensated hypogonadism is prevalent in men with sickle cell disease (SCD). This condition, characterized by normal testosterone and elevated luteinizing hormone (LH), requires further investigation and monitoring in SCD patients.
Area of Science:
- Endocrinology
- Hematology
- Men's Health
Background:
- Sickle cell disease (SCD) is linked to hypogonadism, but its causes and effects remain debated.
- Hypogonadism in SCD can impact patient health and quality of life.
Purpose of the Study:
- To determine the prevalence of hypogonadism in men with SCD.
- To investigate the underlying causes of hypogonadism in this population.
Main Methods:
- A cross-sectional study involving 34 adult men with SCD.
- Measurement of total testosterone, free testosterone, LH, and FSH levels.
- Classification of hypogonadism based on testosterone and LH levels.
Main Results:
- The study found a high prevalence of compensated hypogonadism (26.4%) and eugonadism (67.5%).
- No cases of primary hypogonadism were observed.
- Compensated hypogonadism was associated with elevated FSH levels.
Conclusions:
- Compensated hypogonadism is a significant finding in men with SCD.
- This distinct clinical entity warrants further research and clinical attention.
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