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Chronic urticaria in children - New insights from a large cohort

Idit Lachover-Roth1,2, Ahmad Rabie2, Anat Cohen-Engler1

  • 1Allergy and Clinical Immunology Unit, Meir Medical Center, Kfar-Saba, Israel.

Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology
|January 27, 2021
PubMed

Insights

Pediatric chronic spontaneous urticaria (CSU) is often self-limiting with a good prognosis. Children with CSU frequently have atopic diseases, suggesting a potential TH2-related subgroup.

Area of Science:

  • Pediatric Allergy and Immunology
  • Dermatology
  • Clinical Immunology

Background:

  • Chronic spontaneous urticaria (CSU) is less understood in children compared to adults.
  • Understanding pediatric CSU is crucial for diagnosis and management.

Purpose of the Study:

  • To characterize the demographics, clinical features, comorbidities, and outcomes of pediatric CSU.
  • To identify potential subgroups within pediatric CSU.

Main Methods:

  • Retrospective study of children (up to 18 years) diagnosed with CSU between 2002-2018.
  • Data extracted from electronic medical records at a tertiary referral center.

Main Results:

  • 250 children met CSU criteria; 54.4% were female, mean age 11.4 years.
  • 83.2% of cases resolved within 24 months; 34.8% had atopic comorbidities.
  • 7.2% had autoimmune disease, including 3.6% with thyroid disease.

Conclusions:

  • Pediatric CSU is generally self-limited with a favorable prognosis.
  • Higher prevalence of atopic diseases suggests a possible TH2-related CSU subgroup in children.
Abstract

Keywords:
allergyatopic diseasechildrenchronic spontaneous urticariaurticaria

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