Related Experiment Video
Updated: Nov 19, 2025
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Genetics and Epigenetics of Nasal Polyposis: A Systematic Review
M J Martin1,2,3, A Garcia-Sanchez1,2,4, M Estravis1,2,4
1IBSAL, Institute of Biomedical Research of Salamanca, Salamanca, Spain.
Journal of Investigational Allergology & Clinical Immunology
|January 27, 2021
Summary
Genetic and epigenetic variations are crucial in chronic rhinosinusitis with nasal polyposis (CRSwNP). This review compiles over 150 genetic variants and 89 miRNAs, offering insights for targeted CRSwNP treatments.
Area of Science:
- Genetics and Epigenetics
- Immunology
- Otolaryngology
Background:
- Chronic rhinosinusitis with nasal polyposis (CRSwNP) is a complex inflammatory upper airway disease.
- Genetic and environmental factors are implicated in CRSwNP pathogenesis.
- Understanding these factors is key to developing effective treatments.
Purpose of the Study:
- To systematically review genetic and epigenetic variations associated with CRSwNP since 2000.
- To identify genes, genetic variants, and microRNAs (miRNAs) involved in CRSwNP.
- To explore potential gene-miRNA interactions for future research.
Main Methods:
- Systematic literature review of studies published from 2000 onwards.
- Inclusion of articles focusing on genetic and epigenetic factors in CRSwNP.
- Analysis and synthesis of identified genetic variants, genes, and miRNAs.
Main Results:
- 104 articles were reviewed, with 24 focusing on epigenetics.
- Over 150 genetic variants in 99 genes linked to CRSwNP pathogenesis were identified.
- 89 miRNAs associated with cell cycle, inflammation, and immune response were found, forming 8 gene networks.
Conclusions:
- Genetic and epigenetic factors significantly contribute to CRSwNP development.
- Identified gene variants and miRNAs provide potential therapeutic targets.
- Further research into gene-miRNA interactions could lead to personalized CRSwNP treatments.
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