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Updated: Nov 19, 2025

Polyethyleneimine-coated Iron Oxide Nanoparticles as a Vehicle for the Delivery of Small Interfering RNA to Macrophages In Vitro and In Vivo
Published on: February 5, 2019
Multivalency in CXCR4 chemokine receptor targeted iron oxide nanoparticles
Neazar E Baghdadi1, Benjamin P Burke2, Tahani Alresheedi3
1Centre of Nanotechnology, King Abdul-Aziz University, Jeddah, Saudi Arabia and Department of Chemistry, University of Hull, Cottingham Road, Hull, HU6 7RX, UK. s.j.archibald@hull.ac.uk.
Abstract:
The CXCR4 chemokine receptor is an important biomolecular target in cancer diagnostics and therapeutics. In a new multivalent approach, iron oxide nanoparticles were conjugated with multiple binding units of a low affinity azamacrocylic CXCR4 antagonist. The silica coated nanostructure has good suspension stability, a mode size of 72 nm and high affinity for CXCR4, showing >98% inhibition of anti-CXCR4 mAb binding in a receptor binding competition assay on Jurkat cells.
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